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KMID : 0605820120190020055
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Korean Journal of Pediatric Infectious Diseases
2012 Volume.19 No. 2 p.55 ~ p.60
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Immunoassay of Pertussis According to Ages
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Lee Soo-Young
Choi Ui-Yoon
Kim Ju-sang
Ahn Joong-Hyun
Choi Jung-Hyun
Ma Sang-Hyuk
Park Joon-Soo
Kim Hwang-Min
Kang Jin-Han
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Abstract
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Purpose: We conducted the immunoassay of pertussis according to ages, in order to evaluate protective immunity against pertussis in Korean populations.
Methods: Healthy subjects were enrolled at four university hospitals in Korea. The subjects were grouped as seven age groups (every 10 years). Antibodies against pertussis toxin (PT) in sera were measured by enzyme linked immunosorbent assay (ELISA) kits. Geometric mean concentrations (GMC) of antibodies and the ratios of the subjects with seroprotective antibody levels were determined. The subjects with antibody titers ≥24.0 EU/mL were considered to seroprotective as the manufacturer’s protocol.
Results: Total 1,605 subjects (age: 2 months-65 years) participated in this study, and their GMC was 56.16±50.54 EU/mL. Among seven age groups, age group <11 year showed the highest GMC (64.78±53.24 EU/mL) (P <0.001). In the analysis of the ratios of the subjects with seroprotective antibody titers, 68.2% of the subjects were proven to seroprotective, and age group <11 year also showed the highest ratio (76.5%) (P <0.001).
Conclusions: We found that adolescences or adults (age group ≥11 year) showed lower levels of antibody against pertussis and lower ratio of the subjects with seroprotective antibody titers than children (age group <11 year).
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KEYWORD
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Pertussis, Immunoassay, Immunization, Booster
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